We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cigarette smoking, oral moist snuff use and glucose intolerance.
- Authors
Persson, P.-G.; Carlsson, S.; Svanström, L.; Östenson, C.-G.; Efendic, S.; Grill, V.; Svanström, L; Ostenson, C G
- Abstract
<bold>Objective: </bold>To investigate the association between cigarette smoking and use of oral moist snuff and impaired glucose tolerance and type 2 diabetes.<bold>Design: </bold>We performed a population-based cross-sectional study of glucose intolerance and tobacco use in Stockholm during 1992-94. The sample consisted of 3128 men, aged 35-56 years, of whom 52% had a family history of diabetes. In an oral glucose tolerance test, we detected 55 men with type 2 diabetes and 172 with impaired glucose tolerance. Information on cigarette smoking and oral moist snuff use was collected by a questionnaire.<bold>Results: </bold>The odds ratio of type 2 diabetes was increased for smokers of 25+ cigarettes day-1 (odds ratio = 2.6, 95% confidence interval = 1.1-5.9) as well as for moist snuff dippers of 3+ boxes week-1 (odds ratio = 2.7, 95% confidence interval = 1.3-5.5). The odds ratio of relatively high (highest tertile) fasting insulin levels in subjects with impaired glucose tolerance associated with cigarette smoking of 25+ cigarettes day-1 was 1.5 (95% confidence interval = 0.7-3.6). The corresponding estimate of a relatively low (lowest tertile) 2 h insulin response was 2.5 (95% confidence interval = 0.9-7.1).<bold>Conclusions: </bold>These results indicate that heavy users of cigarettes or moist snuff have an increased risk of type 2 diabetes. The results could suggest that tobacco use is associated with a low insulin response.
- Subjects
SWEDEN; STOCKHOLM (Sweden); TYPE 2 diabetes risk factors; SMOKING; SNUFF; HEALTH; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; TYPE 2 diabetes; POISONOUS plants; RESEARCH; SMOKELESS tobacco; EVALUATION research; CROSS-sectional method; GLUCOSE intolerance; ODDS ratio
- Publication
Journal of Internal Medicine, 2000, Vol 248, Issue 2, p103
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1046/j.1365-2796.2000.00708.x