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- Title
VIP Decreases TLR4 Expression Induced by LPS and TNF-α Treatment in Human Synovial Fibroblasts.
- Authors
JUARRANZ, Y.; GUTIÉRREZ‐CAÑAS, I.; ARRANZ, A.; MARTÍNEZ, C.; ABAD, C.; LECETA, J.; PABLOS, J.L.; GOMARIZ, R.P.
- Abstract
It has been demonstrated that VIP produces beneficial effects both in a murine model of rheumatoid arthritis and in human rheumatoid synovial fibroblasts through the modulation of proinflammatory mediators. Toll-like receptors (TLRs) play a key role in the immediate recognition of microbial surface components by immune cells prior to the development of adaptative microbe-specific immune responses. In this study, we demonstrate that VIP decreases lipopolysaccharide (LPS) and TNF-α-induced expression of TLR4 and its correlation with the production of CCL2 and CXCL8 chemokines in human synovial fibroblasts from patients with rheumatoid arthritis and osteoarthritis. Our results add a new step for the use of VIP, as a promising candidate, for the treatment of rheumatoid arthritis.
- Subjects
VASOACTIVE intestinal peptide; RHEUMATOID arthritis; FIBROBLASTS; MICROBIAL surfactants; ENDOTOXINS; OSTEOARTHRITIS
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1070, Issue 1, p359
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1317.045