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- Title
Interactive Effect of Interleukin-6 and Prostaglandin E<sub>2</sub> on Osteoclastogenesis via the OPG/RANKL/RANK System.
- Authors
LIU, XIN‐HUA; KIRSCHENBAUM, ALEXANDER; YAO, SHEN; LEVINE, ALICE C.
- Abstract
The OPG/RANKL/RANK system regulates osteoclastogenesis. Both cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) and interleukin-6 (IL-6) are reported to induce osteoclast differentiation. The mechanisms underlying these signaling pathways on the OPG/RANKL/RANK system are not fully understood. We herein demonstrate that COX-2 and PGE2 stimulated osteoclastogenesis through inhibition of OPG secretion, stimulation of RANKL production by osteoblasts, and upregulation of RANK expression in osteoclasts. PGE2 also stimulated IL-6 production, and IL-6, in turn, increased PGE2 secretion, COX-2, and EP4/EP2 expression in bone cells. These findings provide evidence of interactive effect of PGE2 and IL-6 signaling pathways in osteoclastogenesis via effect on the OPG/RANKL/RANK system.
- Subjects
OSTEOCLASTS; INTERLEUKINS; PROSTAGLANDINS; CYCLOOXYGENASE 2; BONE cells
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1068, Issue 1, p225
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1346.047