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- Title
Optimal Cutoff Point of Glutamate Decarboxylase Antibody Titers in Differentiating Two Subtypes of Adult-Onset Latent Autoimmune Diabetes.
- Authors
LI, X.; ZHOU, Z. G.; HUANG, G.; YAN, X.; YANG, L.; CHEN, X. Y.; WANG, J. P.
- Abstract
The optimal cutoff point of glutamate decarboxylase antibody (GAD-Ab) titers for differentiating two latent autoimmune diabetes (LADA) subtypes remains unclear. One hundred and forty-five GAD-Ab-positive patients screened from phenotypic type 2 diabetes were diagnosed as LADA. The clinical features were compared among LADA patients with different GAD-Ab titers. The receiver-operating characteristic (ROC) curve was used to evaluate the diagnostic value of GAD-Ab titers and to define the optimal cutoff point. The heterogeneity of clinical features in LADA could be discriminated by five GAD-Ab titers, with maximal differences at the titer of 175 U/mL. The ROC curve analysis showed that the optimal cutoff point for discriminating two LADA subtypes was at the titer of 175 U/mL, with sensitivity and specificity of 54.5% and 92.1%, respectively. These findings demonstrated that the two clinically distinct subtypes of LADA can be optimally discriminated by the GAD-Ab titers.
- Subjects
CARBOHYDRATE intolerance; DIABETIC acidosis; DIABETES; GLUTAMATE decarboxylase; IMMUNOGLOBULINS
- Publication
Annals of the New York Academy of Sciences, 2004, Vol 1037, Issue 1, p122
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1337.019