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- Title
Indian Perspective On 17<sup>th</sup> St. Gallen: Customizing Local and Systemic Therapies for Indian Women with Breast Cancer.
- Authors
Gupta, Sandhya; Kadayaprath, Geeta; Rohatgi, Nitesh; Garg, Charu; Rangaraju, Ranga Rao
- Abstract
This article gives an overview of consensus statements reached for twelve difficult clinical scenarios discussed at Indian perspective of St. Gallen consensus for customizing local and systemic therapies for breast cancer patients. Pathological states in which breast cancer patients should/should not undergo chemotherapy were analysed. It was agreed upon that post-operative radiation is associated with decreased recurrence rates across all subgroups of DCIS and was found to have a survival benefit too. Surgeons recommended re-sentinel procedures instead of complete axillary dissection in women with ipsilateral breast recurrence and negative nodes on imaging after previous treatment with breast conserving surgery and sentinel node mapping. Radiation oncologists established that hypofractionation is a safe and effective radiation technique for breast cancer. Indian experts advised against the addition of carboplatin to standard "dose-dense AC and paclitaxel" or other cyclophosphamide-/anthracycline-/taxane-type regimen and recommended the usage of anthracyclines in a case of HER2-positive node-negative breast cancer receiving taxane-based chemotherapy and anti-HER2 antibodies. They supported adjuvant chemotherapy after neoadjuvant endocrine therapy if there was any evidence of any residual lymph nodal involvement or residual breast lump > 5 cm. Indian oncologists favoured that de novo oligometastatic disease with single bone-only metastases should be treated with curative intent. In patients with more sites of metastatic cancer, such as three or more bone lesions, experts were split between curative and palliative intents.
- Subjects
INDIA; BREAST cancer prognosis; GENETICS; METASTASIS; ESTROGEN; CANCER relapse; DECISION making in clinical medicine; COMBINED modality therapy; BREAST tumors
- Publication
Indian Journal of Surgery, 2022, Vol 84, p616
- ISSN
0972-2068
- Publication type
Article
- DOI
10.1007/s12262-022-03398-0