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- Title
Uncharted territories: Solving the mysteries of male meiosis in flies.
- Authors
Lee, LingSze; Rosin, Leah F.
- Abstract
The segregation of homologous chromosomes during meiosis typically requires tight end-to-end chromosome pairing. However, in Drosophila spermatogenesis, male flies segregate their chromosomes without classic synaptonemal complex formation and without recombination, instead compartmentalizing homologs into subnuclear domains known as chromosome territories (CTs). How homologs find each other in the nucleus and are separated into CTs has been one of the biggest riddles in chromosome biology. Here, we discuss our current understanding of pairing and CT formation in flies and review recent data on how homologs are linked and partitioned during meiosis in male flies.
- Subjects
HOMOLOGOUS chromosomes; CHROMOSOME segregation; FLIES; FORMATION flying; MEIOSIS; CHROMOSOMES
- Publication
PLoS Genetics, 2024, Vol 20, Issue 3, p1
- ISSN
1553-7390
- Publication type
Article
- DOI
10.1371/journal.pgen.1011185