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- Title
Selenium Attenuates Adriamycin-Induced Cardiac Dysfunction via Restoring Expression of ATP-Sensitive Potassium Channels in Rats.
- Authors
Liu, Zhong-Wei; Niu, Xiao-Lin; Chen, Kun-Lun; Xing, Yu-Jie; Wang, Xuan; Qiu, Chuan; Gao, Deng-Feng
- Abstract
The possible mechanism of adriamycin (ADR) and/or selenium (Se) deficiency-induced cardiac dysfunction, and cardioprotective effects of Se against ADR-induced cardiac toxicity were investigated in this study. Cardiac function was evaluated by plasma brain natriuretic peptide level and echocardiographic and hemodynamic parameters. Cardiac glutathione peroxidase (GPx) activity was assessed spectrophotometrically. Expression of ATP-sensitive potassium channels (K) subunits-SUR2A and Kir6.2-were examined by real-time PCR and Western blotting. The results showed that cardiac function and cardiac GPx activity decreased remarkably after administration of ADR or Se deficiency; more dramatic impairment of cardiac function and cardiac GPx activity were observed after co-administration of ADR and Se deficiency. Mechanically, it is novel for us to find down-regulation of K subunits gene expression in cardiac tissue after administration of ADR or Se deficiency, and more significant inhibition of cardiac K gene expression was identified after co-administration of ADR and Se deficiency. Furthermore, cardiac toxicity of ADR was found alleviated by Se supplementation, accompanied by restoring of cardiac GPx activity and cardiac K gene expression. These results indicate that decreased expression of cardiac K is involved in adriamycin and/or Se deficiency-induced cardiac dysfunction; Se deficiency exacerbates adriamycin-induced cardiac dysfunction by future inhibition of K expression; Se supplementation seems to protect against adriamycin-induced cardiac dysfunction via restoring K expression, showing potential clinical application in cancer chemotherapy.
- Subjects
DOXORUBICIN; PHYSIOLOGICAL effects of selenium; GLUTATHIONE peroxidase; CARDIOTONIC agents; CANCER treatment; PHYSIOLOGICAL effects of chemotherapy
- Publication
Biological Trace Element Research, 2013, Vol 153, Issue 1-3, p220
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-013-9641-8