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- Title
Efficient Synthetic Approach to Substituted Benzo[ b]furans and Benzo[ b]thiophenes by Iodine-Promoted.
- Authors
Labarrios, Ehecatl; Jerezano, Alberto; Jiménez, Fabiola; Carmen Cruz, María; Delgado, Francisco; Zepeda, L. Gerardo; Tamariz, Joaquín
- Abstract
An efficient synthetic approach to the substituted benzo[ b]furan and benzo[ b]thiophene scaffolds by iodine-mediated of the corresponding enaminones is described. This protocol was applied to a large series of these latter precursors to afford the respective benzoheterocycles substituted at the C-2 position by a carbonyl group functionality. A study of the factors that control this process reveals that the reactivity depends on the presence of electron-donor groups in the aryl ring of the aryloxycarbonylic and arylthiocarbonylic moieties.
- Subjects
FURANS synthesis; THIOPHENES; CHEMICAL synthesis; BENZENE compound synthesis; IODINE; THIOL derivatives
- Publication
Journal of Heterocyclic Chemistry, 2014, Vol 51, Issue 4, p954
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1686