We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Understanding of lipid transfer protein sensitization patterns and its clinical significance in children.
- Authors
Kazancioglu, Alp; Konuralp, Ilteber; Sahiner, Umit Murat; Soyer, Ozge; Sekerel, Bulent Enis
- Abstract
Background: Lipid transfer proteins (LTP) are the most common food allergens in the Mediterranean region. Objective: The study aimed to investigate co-sensitization patterns and chister relationships between LTP allergen molecules across a broad range of allergen-specific sensitization patterns, and clinical outcomes in eastern Mediterranean children. Methods: Among 496 children evoluated jor multiple sensitizations with multiplex testing, 105 children (21%) with 16 different LTP sensitizations were analyzed. Clinical reactivity was examined based on clear-cut histoiy Of immunoglobulin E mediated symptoms Coral allergy syndroine [OAS], systemic reactions, and anaphylaxis). Results: All children included were sensitive tofood LTPs, but 56 % were sensitive to pollen LTPs. The number of children with OAS and clinical reactivity was 12 and 59, respectively, and no cofactors were reported. The most common selisitizations were Prit p 3 (74%) and Cor a 8 (66%). Significant correlations were observed in the heatillap between the LTP molecules other than Par j 2 and Tri a 14. Overall, clinical reactivity was associated with increased age and number of LTP molecule posttivity. Conclusion: In the eastern Mediterranean region, 21% of children with multiple food and/or pollen sensitizations were found to have LTP sensitization; however, almost half reported clinical reactivity. The hierarchical pathway highlights that distinct LTP allergen molecules can act as primary sensitizers. Clinical reactivity is linked to increasing numbers OfLTP molecule positivity and increasing age.
- Subjects
ORGANIZATION of American States; LIPID transfer protein; IMMUNOGLOBULIN E; CHILD nutrition
- Publication
Allergy & Asthma Proceedings, 2024, Vol 45, Issue 2, p120
- ISSN
1088-5412
- Publication type
Article
- DOI
10.2500/aap.2024.45.230075