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- Title
Is Viloxazine an Antidepressant? A Placebo-controlled Double-blind Study in Major Depressive Disorder Presenting in a General Hospital.
- Authors
Thompson, C.; Isaacs, G.
- Abstract
Viloxazine was one of the first of the 'second-generation' antidepressants. Its relative lack of cardiotoxic, anticholinergic, sedative and seizure-inducing adverse effects suggested its use as an antidepressant in general hospitals where tricyclic antidepressants might be frequently contraindicated. We conducted a double-blind trial of 300mg viloxazine against placebo in 43 patients with major depressive disorder. The placebo-treated group showed a slightly, but not significantly, greater improvement in depression scores using observer and self-rating scales over those using viloxazine. A review of previous placebo-controlled studies of viloxazine offers little support to its use as an antidepressant.
- Subjects
ANTIDEPRESSANTS; PSYCHIATRIC drugs; MENTAL depression; HOSPITALS; PLACEBOS; DEPRESSED persons
- Publication
Human Psychopharmacology: Clinical & Experimental, 1991, Vol 6, Issue 1, p31
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.470060106