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- Title
Administration of ferrocene‐modified amino acids induces changes in synaptic transmission in the CA1 area of the hippocampus.
- Authors
Rodionov, Alexey N.; Snegur, Lubov V.; Dobryakova, Yulia V.; Ilyin, Mikhail M.; Markevich, Vladimir A.; Simenel, Alexander A.
- Abstract
A series of ferrocene‐modified amino acid methyl esters with pyrazole linker was prepared in good to quantitative yields starting from easy accessible ferrocene pyrazole carbaldehyde and amino acids in racemic and enantio enriched forms under reductive amination conditions (NaBH (OAc)3, reflux, 3 hr). The resulting enantiomers were resolved using analytical HPLC on modified cellulose or amylose as chiral selectors. In vivo electrophysiological experiments were performed in the CA1 field of the hippocampus on 3a Fc‐Gly, (L)‐3b Fc‐Ala, and (D)‐3b Fc‐Ala compounds. An increasing in the amplitudes of responses of local potentials (up to 25%) of the CA1 region in the studied groups was found after intraperitoneal administration of ferrocene compounds 3a and (D)‐3b compared with control rats treated with saline.
- Subjects
AMINO acids; NEURAL transmission; TARTARIC acid; METHYL formate; HIPPOCAMPUS (Brain)
- Publication
Applied Organometallic Chemistry, 2020, Vol 34, Issue 3, pN.PAG
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.5276