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- Title
Myocardial fibrosis evaluated by diffusion-weighted imaging and its relationship to 3D contractile function in patients with hypertrophic cardiomyopathy.
- Authors
Wu, Rui; An, Dong‐Aolei; Shi, Ruo‐Yang; Chen, Bing‐hua; Jiang, Meng; Bacyinski, Andrew; Han, Tong‐Tong; Hu, Jiani; Xu, Jian‐Rong; Wu, Lian‐Ming; An, Dong-Aolei; Shi, Ruo-Yang; Chen, Bing-Hua; Han, Tong-Tong; Xu, Jian-Rong; Wu, Lian-Ming
- Abstract
<bold>Background: </bold>Previous studies have shown that diffusion-weighted imaging (DWI) is sensitive to myocardial fibrosis in ischemic and nonischemic cardiomyopathy.<bold>Purpose: </bold>To explore the prognostic value of apparent diffusion coefficient (ADC) for detecting myocardial fibrosis and its relationship to the contractile function in hypertrophic cardiomyopathy (HCM).<bold>Study Type: </bold>Prospective.<bold>Population: </bold>A total of 45 HCM patients and 20 controls.<bold>Field Strength/sequence: </bold>3.0T cardiac MRI. The cardiac MR sequences included cine, T1 mapping, and DWI.<bold>Assessment: </bold>According to the presence of late gadolinium enhancement (LGE) and the extracellular volume (ECV) values (+2 SD of control subjects), respectively, reader W and reader J assessed the value of ADC of each segment for detecting myocardial fibrosis and its relationship to impaired contractile function in HCM patients.<bold>Statistical Tests: </bold>Independent sample t-test, Pearson analysis, and intraclass correlation (ICC).<bold>Results: </bold>The value of ECV was 23.6 ± 3.0% for control. ECV ≥ 29.6% and ECV < 29.6% groups were classified. ADC values in the ECV ≥ 29.6% group were significantly increased compared to the ECV < 29.6% group, (2.41 ± 0.23 μm2 /ms vs. 2.03 ± 0.16 μm2 /ms, P < 0.005). Compared to the LGE - group, ECV (32.1 ± 2.3% vs. 29.0 ± 2.8%, P < 0.005) and ADC (2.60 ± 0.18 μm2 /ms vs. 2.10 ± 0.07 μm2 /ms, P < 0.005) values were significantly increased in the LGE + group. ADC values were linearly associated with ECV values (R2 = 0.65) in HCM patients. ADC values were linearly associated with circumferential and longitudinal strain (R2 = 0.60, R2 = 0.46), as well as circumferential, longitudinal, and radial strain rate (R2 = 0.13, R2 = 0.25, R2 = 0.17, respectively).<bold>Data Conclusion: </bold>Contractile dysfunction in HCM is predominantly associated with ADC, which is a feasible alternative to ECV and LGE for detecting myocardial fibrosis.<bold>Level Of Evidence: </bold>1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1139-1146.
- Publication
Journal of Magnetic Resonance Imaging, 2018, Vol 48, Issue 4, p1139
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.26016