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- Title
Estimating the arterial input function from dynamic contrast-enhanced MRI data with compensation for flow enhancement (II): Applications in spine diagnostics and assessment of crohn's disease.
- Authors
van Schie, Jeroen J. N.; Lavini, Cristina; van Vliet, Lucas J.; Kramer, Gem; Pieters ‐ van den Bos, Indra; Marcus, J. T.; Stoker, Jaap; Vos, Frans M.; Pieters-van den Bos, Indra
- Abstract
<bold>Background: </bold>Pharmacokinetic (PK) models can describe microvascular density and integrity. An essential component of PK models is the arterial input function (AIF) representing the time-dependent concentration of contrast agent (CA) in the blood plasma supplied to a tissue.<bold>Purpose/hypothesis: </bold>To evaluate a novel method for subject-specific AIF estimation that takes inflow effects into account.<bold>Study Type: </bold>Retrospective study.<bold>Subjects: </bold>Thirteen clinical patients referred for spine-related complaints; 21 patients from a study into luminal Crohn's disease with known Crohn's Disease Endoscopic Index of Severity (CDEIS).<bold>Field Strength/sequence: </bold>Dynamic fast spoiled gradient echo (FSPGR) at 3T.<bold>Assessment: </bold>A population-averaged AIF, AIFs derived from distally placed regions of interest (ROIs), and the new AIF method were applied. Tofts' PK model parameters (including vp and Ktrans ) obtained with the three AIFs were compared. In the Crohn's patients Ktrans was correlated to CDEIS.<bold>Statistical Tests: </bold>The median values of the PK model parameters from the three methods were compared using a Mann-Whitney U-test. The associated variances were statistically assessed by the Brown-Forsythe test. Spearman's rank correlation coefficient was computed to test the correlation of Ktrans to CDEIS.<bold>Results: </bold>The median vp was significantly larger when using the distal ROI approach, compared to the two other methods (P < 0.05 for both comparisons, in both applications). Also, the variances in vp were significantly larger with the ROI approach (P < 0.05 for all comparisons). In the Crohn's disease study, the estimated Ktrans parameter correlated better with the CDEIS (r = 0.733, P < 0.001) when the proposed AIF was used, compared to AIFs from the distal ROI method (r = 0.429, P = 0.067) or the population-averaged AIF (r = 0.567, P = 0.011).<bold>Data Conclusion: </bold>The proposed method yielded realistic PK model parameters and improved the correlation of the Ktrans parameter with CDEIS, compared to existing approaches.<bold>Level Of Evidence: </bold>3 Technical Efficacy Stage 1 J. Magn. Reson. Imaging 2018;47:1197-1204.
- Publication
Journal of Magnetic Resonance Imaging, 2018, Vol 47, Issue 5, p1197
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25905