We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Combination CCNU and vinblastine chemotherapy for canine mast cell tumours: 57 cases.
- Authors
Cooper, Maureen; Tsai, XinRu; Bennett, Peter
- Abstract
The purpose of this study was to evaluate the efficacy and toxicity of a CCNU and vinblastine chemotherapy protocol for canine mast cell tumours. Fifty-seven tumours in 56 dogs were evaluated, 37 had macroscopic disease and 20 had microscopic disease. A 57% response rate was seen in dogs with macroscopic disease for a median duration of 52 weeks. Dogs with macroscopic disease had a median progression free survival time (PFST) of 30 weeks and a median overall survival time (OST) of 35 weeks. Dogs with microscopic disease had a median PFST of 35 weeks and a median OST of 48 weeks. Toxicity was recorded in 54% of the dogs treated, with the majority of events being mild. This chemotherapy protocol appears to be well tolerated and should be considered for canine mast cell tumours.
- Subjects
VINBLASTINE; DRUG therapy; DOG diseases; TUMORS in animals; MAST cells; VETERINARY oncology; VETERINARY medicine
- Publication
Veterinary & Comparative Oncology, 2009, Vol 7, Issue 3, p196
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/j.1476-5829.2009.00190.x