We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dickkopf-1 level is lower in patients with ankylosing spondylitis than in healthy people and is not influenced by anti-tumor necrosis factor therapy.
- Authors
Kwon, Seong-Ryul; Lim, Mie-Jin; Suh, Chang-Hee; Park, Shin-Goo; Hong, Yeon-Sik; Yoon, Bo-Young; Kim, Hyoun-Ah; Choi, Hyo-Jin; Park, Won
- Abstract
(1) To compare the serum levels of Dickkopf-1 (DKK-1) and bone biomarkers in patients with ankylosing spondylitis (AS) and healthy controls. (2) To examine the effects of anti-tumor necrosis factor-α (TNF-α) therapy for 3 months on bone biomarkers in patients with AS. We measured the levels of DKK-1, osteocalcin, osteoprotegerin, and C-terminal telopeptide of type I collagen (CTX-1) in patients with AS and in healthy controls at baseline and 3 months after initiating anti-TNF-α therapy in AS patients. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were also measured before and after anti-TNF-α therapy in AS patients. Serum levels of DKK-1 were significantly lower in the AS patients than in the controls ( P < 0.0001). Osteocalcin and osteoprotegerin levels were significantly higher in the AS patients than in the controls ( P < 0.0001). Serum levels of DKK-1 were not changed after the 3-month anti-TNF-α therapy. Osteocalcin level increased ( P < 0.0001), osteoprotegerin level and BASDAI scores decreased ( P = 0.025 and P < 0.0001, respectively) significantly after the 3-months anti-TNF-α therapy. Serum DKK-1 level was lower in patients with AS than in healthy controls and did not change after 3 months of anti-TNF-α therapy in the AS patients despite the marked improvement in BASDAI scores. These findings suggest the low serum DKK-1 level is related to the pathogenesis of new bone formation in AS, which is resistant to TNF-α blocking therapy.
- Subjects
ANKYLOSING spondylitis; BIOMARKERS; TUMOR necrosis factors; OSTEOCALCIN; OSTEOPROTEGERIN
- Publication
Rheumatology International, 2012, Vol 32, Issue 8, p2523
- ISSN
0172-8172
- Publication type
Article
- DOI
10.1007/s00296-011-1981-0