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- Title
Experimental study of calcium phosphate cement impregnated with dideoxy-kanamycin B.
- Authors
Osamu Kisanuki; Hiroshi Yajima; Tomohiro Umeda; Yoshinori Takakura
- Abstract
Abstract Background  The present study was undertaken to examine whether antibiotic-impregnated calcium phosphate cement (CPC) would provide a valid means of treating osteomyelitis. Methods  The antibiotic used for the impregnation was dideoxy-kanamycin B (DKB), which is available in two forms (powder and liquid). Columnar test specimens (diameter 7âmm, height 14âmm) were prepared by adding the liquid or powdered DKB. Group A: Three types (6.25-titer, 12.5-titer, 25-titer) of test specimen were prepared by mixing the setting solution and DKB solutions into cement. Group B: Three types (25-titer, 50-titer, 100-titer) of test specimen were prepared by mixing the setting solution and DKB powder into cement. Group C: A control specimen was prepared by mixing the setting solution into the cement. The study included a consistency test, setting-time test, compressive strength test, porosity test, and elution test. Results  The value for the consistency test was >23âmm in all test groups. The results of the setting-time test showed that the setting time became significantly longer as the DKB content increased for groups A group B. Compressive strength decreased as the antibiotic content increased, although all specimens remained sufficiently strong for clinical application. In group A the porosity did not differ significantly depending on the antibiotic content, whereas in group B the porosity increased significantly as the antibiotic content increased. In the elution test using specimens with the same titer (25 titer), the elution efficiency was higher in group A than in group B, and the duration of elution was longer in group A. Conclusions  Although polymethylmethacrylate (PMMA) has been conventionally used as a drug-delivery system (DDS), the results of the present study indicate that CPC shows better elution efficiency than PMMA. It is thus a promising DDS for the treatment of osteomyelitis.
- Subjects
ANTIBIOTICS; CALCIUM phosphate; OSTEOMYELITIS; POROSITY; POLYMETHYLMETHACRYLATE
- Publication
Journal of Orthopaedic Science, 2007, Vol 12, Issue 3, p281
- ISSN
0949-2658
- Publication type
Article
- DOI
10.1007/s00776-007-1124-3