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- Title
Flash Electrochemical Approach to Carbocations.
- Authors
Takumi, Masahiro; Sakaue, Hodaka; Nagaki, Aiichiro
- Abstract
A novel flow electrochemical reactor that accomplishes electrolysis within a few seconds in a single passage was developed. By using the flow reactor system, the flash electrochemical generation of short‐lived carbocations, including oxocarbenium ions, N‐acyliminium ions, glycosyl cations, and Ferrier cations was achieved within a few seconds, enabling the subsequent reaction with nucleophiles before their decomposition. Moreover, continuous operation based on the present system enabled the rapid synthesis of pharmaceutical precursors on demand.
- Subjects
CARBOCATIONS; FLOW chemistry; IONS; NUCLEOPHILES; CATIONS; ELECTROLYSIS
- Publication
Angewandte Chemie, 2022, Vol 134, Issue 10, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202116177