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- Title
Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells.
- Authors
Gomes, Ana T. P. C.; Neves, M. Graça P. M. S.; Fernandes, Rosa; Ribeiro, Carlos F.; Cavaleiro, José A. S.; Moura, Nuno M. M.
- Abstract
In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs' derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells' viability. This creates an avenue to further studies related to bladder cancer cells.
- Subjects
BLADDER cancer; CANCER cells; PHOTOSENSITIZERS; METALLOPORPHYRINS; REACTIVE oxygen species; CELL survival; ZINC porphyrins
- Publication
Molecules, 2021, Vol 26, Issue 17, p5312
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26175312