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- Title
Synthesis and Cytotoxic Activity Study of Novel 2-(Aryldiazenyl)-3-methyl-1 H -benzo[ g ]indole Derivatives.
- Authors
Arafeh, Manar M.; Moghadam, Ebrahim Saeedian; Adham, Sirin A. I.; Stoll, Raphael; Abdel-Jalil, Raid J.
- Abstract
A novel series of 2-(aryldiazenyl)-3-methyl-1H-benzo[g]indole derivatives (3a–f) were prepared through the cyclization of the corresponding arylamidrazones, employing polyphosphoric acid (PPA) as a cyclizing agent. All of the compounds (3a–f) were characterized using 1H NMR, 13C NMR, MS, elemental analysis, and melting point techniques. The synthesized compounds were evaluated for cytotoxic activity against diverse human cancer cell lines by the National Cancer Institute. While all of the screened compounds were found to be cytotoxic at a 10 µM concentration, two of them (2c) and (3c) were subjected to five dose screens and showed a significant cytotoxicity and selectivity.
- Subjects
INDOLE derivatives; ELEMENTAL analysis; POLYPHOSPHORIC acid; MELTING points; CHEMICAL synthesis
- Publication
Molecules, 2021, Vol 26, Issue 14, p4240
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26144240