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- Title
Production of Terretonin N and Butyrolactone I by Thermophilic Aspergillus terreus TM8 Promoted Apoptosis and Cell Death in Human Prostate and Ovarian Cancer Cells.
- Authors
Ghfar, Ayman A.; El-Metwally, Mohammad Magdy; Shaaban, Mohamed; Gabr, Sami A.; Gabr, Nada S.; Diab, Marwa S. M.; Aqel, Ahmad; Habila, Mohamed A.; Al-Qahtani, Wahidah H.; Alfaifi, Mohammad Y.; Elbehairi, Serag Eldin I.; AlJumah, Bayan Ahmed; Granchi, Carlotta
- Abstract
The anticancer activity of terretonin N (1) and butyrolactone I (2), obtained from the thermophilic fungus Aspergillus terreus TM8, was intensively studied against prostate adenocarcinoma (PC-3) and ovary adenocarcinoma (SKOV3) human cell lines. According to this study, both compounds showed potent cytotoxicity towards ovarian adenocarcinoma cells (SKOV3) with IC50 1.2 and 0.6 μg/mL, respectively. With respect to metastatic prostate cells (PC-3), the two compounds 1 and 2 showed a significantly promising cytotoxicity effect with IC50 of 7.4 and 4.5 μg/mL, respectively. The tested fungal metabolites showed higher rates of early and late apoptosis with little or no necrotic apoptotic pathway in all treated prostate adenocarcinoma (PC-3) and ovary adenocarcinoma (SKOV3) human cell lines, respectively. The results reported in this study confirmed the promising biological properties of terretonin N (1) and butyrolactone I (2) as anticancer agents via the induction of cellular apoptosis. However, further studies are needed to elucidate the molecular mechanism by which cellular apoptosis is induced in cancer cells.
- Subjects
ASPERGILLUS terreus; PROSTATE cancer; CANCER cells; CELL death; OVARIAN cancer; FUNGAL metabolites
- Publication
Molecules, 2021, Vol 26, Issue 9, p2816
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26092816