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- Title
Plectrabarbene, a New Abietane Diterpene from Plectranthus barbatus Aerial Parts.
- Authors
Al Musayeib, Nawal M.; Amina, Musarat; Al-Hamoud, Gadah Abdulaziz; Mohamed, Gamal A.; Ibrahim, Sabrin R.M.; Shabana, Samah
- Abstract
A new abietane diterpene namely plectrabarbene (2), together with two known compounds: sugiol (1) and 11,14-dihydroxy-8,11,13-abietatrien-7-one (3) have been isolated from the aerial parts of Plectranthus barbatus Andr. (Labiatae). The structures of these compounds were determined by various spectral techniques (e.g., UV, IR, NMR, and FAB) and by comparison with the literature data. A molecular docking study of the isolated diterpenes (1–3) was performed with AChE to gain an insight into their AChE inhibition mechanism. The results of docking experiments revealed that the all tested compounds showed binding affinity at the active site of AchE in comparison to donepezil.
- Subjects
ABIETANE; PLECTRANTHUS; MOLECULAR docking; LAMIACEAE; DITERPENES
- Publication
Molecules, 2020, Vol 25, Issue 10, p2365
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25102365