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- Title
Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor.
- Authors
Němečková, Dana; Havránková, Eva; Šimbera, Jan; Ševčík, Richard; Pazdera, Pavel; Vázquez, Julio A. A. Seijas
- Abstract
We reported a novel simplified synthetic procedure for the preparation of monosubstituted piperazine derivatives which can now be easily prepared in a one-pot-one-step way from a protonated piperazine with no need of introduction of a protecting group. Reactions, proceeding either at room or higher temperatures in common solvents, involve heterogeneous catalysis by metal ions supported on commercial polymeric resins. A general synthetic scheme was successfully applied to afford a wide range of monosubstituted piperazines. Furthermore, we picked up a set of piperazine derivatives and studied the possibilities of microwave acceleration of given synthetic reactions to make them even more efficient. Our research proceeded from a simple batch technique to the construction of a flow microwave reactor prototype and resulted in promising findings which are summarized and discussed in the article.
- Subjects
PIPERAZINE; MICROWAVES; HETEROGENEOUS catalysis; METAL ions; PRESSURIZED water reactors; HIGH temperatures; CATALYST supports
- Publication
Molecules, 2020, Vol 25, Issue 9, p2168
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25092168