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- Title
Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry.
- Authors
Dolar-Szczasny, Joanna; Święch, Anna; Flieger, Jolanta; Tatarczak-Michalewska, Małgorzata; Niedzielski, Przemysław; Proch, Jędrzej; Majerek, Dariusz; Kawka, Justyna; Mackiewicz, Jerzy
- Abstract
Trace elements play an important role in the pathogenesis of several serious ophthalmological disorders, such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, cataract, etc. This study aimed to measure alterations of chemical elements' (67) levels in the aqueous humor of patients undergoing cataract surgery. The pilot study included 115 patients, (age 74 ± 7.27, female 64.35%, male 35.65%). The aqueous levels of elements were measured by the use of the inductively coupled plasma optical emission spectrometry (ICP-OES), quality controlled with certified standards. The classification of elements based on their concentration was achieved by hierarchical cluster analysis. This is the first screening study that quantifies over 60 elements which are present in the fluid from the anterior chamber of the eye of cataract patients. The obtained results can be suitable for understanding and identifying the causes that may play a role in the initiation and progression of lens opacity.
- Subjects
AQUEOUS humor; INDUCTIVELY coupled plasma atomic emission spectrometry; TRACE elements; ANTERIOR chamber (Eye); CHEMICAL elements; HIERARCHICAL clustering (Cluster analysis); CATARACT; PATHOLOGY
- Publication
Molecules, 2019, Vol 24, Issue 22, p4127
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24224127