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- Title
Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis.
- Authors
Da-Le Guo; Xiao-Hua Li; Dan Feng; Meng-Ying Jin; Yu-Mei Cao; Zhi-Xing Cao; Yu-Cheng Gu; Zhao Geng; Fang Deng; Yun Deng
- Abstract
Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC50 values of 23.95 µM and 32.70 µM, respectively.
- Publication
Molecules, 2018, Vol 23, Issue 7, p1709
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23071709