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- Title
Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents.
- Authors
Gomha, Sobhi M.; Farghaly, Thoraya A.; Mabkhot, Yahia Nasser; Zayed, Mohie E. M.; Mohamed, Amany M. G.
- Abstract
In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trimethoprim/sulphamethoxazole. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used.
- Subjects
AZOLES; HETEROCYCLIC compounds synthesis; ANTI-infective agents; IRRADIATION; PHARMACOLOGY
- Publication
Molecules, 2017, Vol 22, Issue 3, p346
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22030346