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- Title
Biocatalytic Synthesis of Novel Partial Esters of a Bioactive Dihydroxy 4-Methylcoumarin by Rhizopus oryzae Lipase (ROL).
- Authors
Kumar, Vinod; Mathur, Divya; Srivastava, Smriti; Malhotra, Shashwat; Rana, Neha; Singh, Suraj K.; Singh, Brajendra K.; Prasad, Ashok K.; Varma, Anjani J.; Len, Christophe; Kuhad, Ramesh C.; Saxena, Rajendra K.; Parmar, Virinder S.
- Abstract
Highly regioselective acylation has been observed in 7,8-dihydroxy-4-methylcoumarin (DHMC) by the lipase from Rhizopus oryzae suspended in tetrahydrofuran (THF) at 45 °C using six different acid anhydrides as acylating agents. The acylation occurred regioselectively at one of the two hydroxy groups of the coumarin moiety resulting in the formation of 8-acyloxy-7-hydroxy-4-methylcoumarins, which are important bioactive molecules for studying biotansformations in animals, and are otherwise very difficult to obtain by only chemical steps. Six monoacylated, monohydroxy 4-methylcoumarins have been biocatalytically synthesised and identified on the basis of their spectral data and X-ray crystal analysis.
- Publication
Molecules, 2016, Vol 21, Issue 11, p1499
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21111499