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- Title
Easy Access to Evans' Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative.
- Authors
Diaz, Gaspar; de Freitas, Michelle A. A.; Ricci-Silva, Maria E.; Diaz, Marisa A. N.
- Abstract
An interesting new approach was developed for the synthesis of Evans' chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections.
- Subjects
OXAZOLIDINONES; ENANTIOSELECTIVE catalysis; CHEMICAL derivatives; STEREOSELECTIVE reactions; BAYLIS-Hillman reaction; STAPHYLOCOCCUS aureus
- Publication
Molecules, 2014, Vol 19, Issue 6, p7429
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules19067429