We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inter-rater reliability and double reading analysis of an automated three-dimensional breast ultrasound system: comparison of two independent examiners.
- Authors
Maier, Anna; Heil, Joerg; Lauer, Anna; Harcos, Aba; Schaefgen, Benedikt; Au, Alexandra; Spratte, Julia; Riedel, Fabian; Rauch, Geraldine; Hennigs, André; Domschke, Christoph; Schott, Sarah; Rom, Joachim; Schuetz, Florian; Sohn, Christof; Golatta, Michael; von Au, Alexandra; Hennigs, André
- Abstract
<bold>Purpose: </bold>Breast ultrasound could be a valuable tool complementary to mammography in breast cancer screening. Automated 3D breast ultrasound (ABUS) addresses challenges of hand-held ultrasound and could allow double reading analysis of ultrasound images. This trial assesses the inter-rater reliability and double reading analysis of an ABUS system.<bold>Methods: </bold>To assess the reproducibility and diagnostic validity of the ABUS system, SomoV™, a blinded double reading analysis, was performed in 1019 patients (2038 breasts) by two examiners (examiner A/B) and compared to single reading results, as well as to the reference standard regarding its diagnostic validity. Cohen's kappa coefficients were calculated to measure the inter-rater reliability and agreement of the different diagnostic modalities. Patient comfort and time consumption for image acquisition and reading were analyzed descriptively as secondary objectives.<bold>Results: </bold>Analysis of inter-rater reliability yielded agreement in 81.6% (κ = 0.37; p < 0.0001) showing fair agreement. Single reading analysis of SomoV™ exams (examiner A/examiner B) compared to reference standard showed good specificity (examiner A: 88.3%/examiner B: 84.5%), fair inter-rater agreement (examiner A: κ = 0.31/examiner B: κ = 0.31), and adequate sensitivity (examiner A: 53.1%/examiner B: 64.2%). Double reading analysis yielded good sensitivity and specificity (73.7 and 77.7%). Mammography (n = 1911) alone detected 160 of 176 carcinomas (sensitivity 90.1%). Adding SomoV™ to mammography would have detected 12 additional carcinomas, resulting in a higher sensitivity of 97.7%.<bold>Conclusion: </bold>SomoV™ is a promising technique with good sensitivity, high patient comfort, and fair inter-examiner reliability. It allows double reading analysis that, in combination with mammography, could increase detection rates in breast cancer screening.
- Subjects
BREAST cancer diagnosis; MAMMOGRAMS; BREAST imaging; ULTRASONIC imaging; THREE-dimensional imaging; MEDICAL imaging systems
- Publication
Archives of Gynecology & Obstetrics, 2017, Vol 296, Issue 3, p571
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s00404-017-4473-y