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- Title
Significance of eukaryotic translation elongation factor 1A in tobacco mosaic virus infection.
- Authors
Yamaji, Yasuyuki; Sakurai, Keitaro; Hamada, Koji; Komatsu, Ken; Ozeki, Johji; Yoshida, Akiko; Yoshii, Atsushi; Shimizu, Takumi; Namba, Shigetou; Hibi, Tadaaki
- Abstract
Eukaryotic translation elongation factor 1A (eEF1A) has been shown to interact with both the viral RNA-dependent RNA polymerase and the 3′-terminal genomic RNA of tobacco mosaic virus (TMV). In this study, we demonstrated that the down-regulation of eEF1A mRNA levels by virus-induced gene silencing using potato virus X vector dramatically reduced the accumulation of TMV RNA and the spread of TMV infection. The translation activity of the eEF1A-silenced Nicotiana benthamiana leaves was not severely affected. Collectively, these results suggest an essential role of eEF1A in TMV infection.
- Subjects
TOBACCO mosaic virus; RNA polymerases; VIRAL genomes; VIRAL genetics; NICOTIANA benthamiana
- Publication
Archives of Virology, 2010, Vol 155, Issue 2, p263
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-009-0571-x