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- Title
Features of Intracellular Signal Transduction in Neural Stem Cells under the Influence of Alkaloid Songorine, an Agonist of Fibroblast Growth Factor Receptors.
- Authors
Zyuz'kov, G. N.; Losev, E. A.; Suslov, N. I.; Miroshnichenko, L. A.; Polyakova, T. Yu.; Simanina, E. V.; Stavrova, L. A.; Agafonov, V. I.; Danilets, M. G.; Zhdanov, V. V.
- Abstract
We performed a comparative in vitro study of the involvement of NF-κB, PI3K, cAMP, ERK1/2, p38, JAKs, STAT3, JNK, and p53-dependent intracellular signaling in the functioning of neural stem cells (NSC) under the influence of basic fibroblast growth factor (FGF) and FGF receptor agonist, diterpene alkaloid songorine. The significant differences in FGFR-mediated intracellular signaling in NSC were revealed for these ligands. In both cases, stimulation of progenitor cell proliferation occurs with the participation of NF-κB, PI3K, ERK1/2, JAKs, and STAT3, while JNK and p53, on the contrary, inhibit cell cycle progression. However, under the influence of songorin, cAMP- and p38-mediated cascades are additionally involved in the transmission of the NSC division-activating signal. In addition, unlike FGF, the alkaloid stimulates progenitor cell differentiation by activating ERK1/2, p38, JNK, p53, and STAT3.
- Subjects
NEURAL stem cells; FIBROBLAST growth factor 2; CELLULAR signal transduction; FIBROBLAST growth factor receptors; FIBROBLAST growth factors; CELL cycle; PROGENITOR cells; ALKALOIDS
- Publication
Bulletin of Experimental Biology & Medicine, 2024, Vol 176, Issue 5, p576
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-024-06070-7