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- Title
Distribution of Ferrihydrite Nanoparticles in the Body and Possibility of Controlling Them in an Isolated Organ by a Permanent Magnetic Field.
- Authors
Inzhevatkin, E. V.; Osipova, E. D.; Shadrin, K. V.; Pakhomova, V. G.; Rupenko, A. P.; Maksimov, N. G.; Ladygina, V. P.; Yaroslavtsev, R. N.; Stolyar, S. V.
- Abstract
We studied the distribution of ferrihydrite nanoparticles isolated from bacteria Klebsiella oxytoca in the whole body in vivo and in a cultured isolated organ (liver). The possibility of controlling these nanoparticles in the body using a magnetic field was assessed. One hour after intravenous injection of ferrihydrite nanoparticles to mice, their accumulation was observed in the liver, lungs, and kidneys. Experiment with cultured isolated rat liver showed that these nanoparticles can be controlled by a magnetic field and the influence of magnetic nanoparticles on the liver over 1 h does not lead to destruction of liver cells associated with the release of the marker enzyme AST. These results show the possibility of using magnetic nanoparticles as a system for controlled drug delivery in the body.
- Subjects
MAGNETIC fields; DRUG delivery systems; MAGNETIC nanoparticles; NANOPARTICLES; LIVER cells; KLEBSIELLA oxytoca
- Publication
Bulletin of Experimental Biology & Medicine, 2020, Vol 168, Issue 6, p789
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-020-04803-y