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- Title
Toxic Effects of Lithium Chloride during Early Neonatal Period of Rat Development.
- Authors
Menshanov, P.; Bannova, A.; Dygalo, N.
- Abstract
Lithium chloride (85, 255, or 255+127 μg/kg) or dexamethasone (0.2 or 2 mg/kg) were subcutaneously injected to 3-day-old rat pups, whose excretory system did not yet attain functional maturity. Both agents retarded the growth of rat pups and delayed the appearance of negative geotaxis. LD and therapeutic index of lithium chloride were 255 μg/kg and TI≤3, respectively. Thus, lithium salts even in low doses can be highly toxic for the developing organism.
- Subjects
LITHIUM chloride; DEXAMETHASONE; MAMMAL development; GEOTAXIS; LABORATORY rats
- Publication
Bulletin of Experimental Biology & Medicine, 2016, Vol 160, Issue 4, p459
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-016-3196-6