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- Title
Poly(ε-Caprolactone) Nerve Conduit and Local Delivery of vegf and fgf2 Genes Stimulate Neuroregeneration.
- Authors
Nikolaev, S.; Gallyamov, A.; Mamin, G.; Chelyshev, Yu.
- Abstract
We studied regeneration of rat sciatic nerve while overcoming of a 5-mm diastasis with the aid of nanostructured conduit made of biocompatible and biodegradable poly(ε-caprolactone) and filled with fibrin hydrogel matrix. Implantation of the conduit into the nerve in combination with local delivery of the expression plasmid carrying genes encoding vascular endothelial growth factor ( vegf) and fibroblast growth factor 2 ( fgf2) leads to an increase in number of myelinated fibers and S-100 cells in the peripheral nerve stump and improved recovery of the nerve function. Under conditions of direct gene therapy, an advantage of electrospun poly(ε-caprolactone) conduit with high-porosity was revealed on the basis of these criteria in comparison with biocompatible silicon conduit.
- Subjects
SCIATIC nerve; REGENERATION (Biology); NERVOUS system regeneration; CAPROLACTONES; POROSITY; GENE therapy
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 157, Issue 1, p155
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2513-1