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- Title
Cardioprotective effect of κ<sub>1</sub>-opioid receptor activation and role of cAMP in its realization.
- Authors
T. Lasukova; L. Maslov; A. Platonov; N. Guzarova; Yu. Lishmanov
- Abstract
Abstract The cardioprotective and antiarrhythmic effects of a selective κ1-opioid receptor agonist U-50,488 were studied during experimental 45-min total ischemia and 30-min reperfusion of isolated rat heart. The opioid had no effect on the incidence and type of reperfusion arrhythmias. U-50,488 in a concentration of 0.1 M inhibited reperfusion-induced release of creatine phosphokinase and decreased cAMP concentration in the myocardium by 2 times. These parameters remained unchanged after treatment with U-50,488 in a concentration of 1 M. The cardioprotective effect of U-50,488 was probably associated with a decrease in cAMP concentration in heart cells. U-50,488 in a concentration of 1 M produced no cardioprotective effect, which can be explained by its interaction with an unknown non-opioid receptor in cardiomyocytes.
- Subjects
OPIOIDS; ISCHEMIA; REPERFUSION injury; HEART cells
- Publication
Bulletin of Experimental Biology & Medicine, 2007, Vol 143, Issue 1, p22
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-007-0007-0