We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Size variations in the lateral intercellular spaces of the endolymphatic sac induced by dietary factors.
- Authors
Wackym, Phillip A.; Canalis, Rinaldo F.; Friberg, Ulla; Rask-Andersen, Helge; Linthicum, Fred H.
- Abstract
Since much evidence suggests that the endolymphatic sac is responsible for endolymph resorption, and that the endolymphatic sac lateral intercellular spaces which are lined by the energy-dependent transport complex Na+, K+-ATPase are important in this process, we sought to evaluate the effects of dietary salt and a food extract that inhibits the activity of Na+, K+-ATPase on lateral intercellular space size. Animals fed this food factor and a high-sodium diet had significantly smaller endolymphatic sac lateral intercellular spaces than those animals fed only a high-sodium diet (analysis of variance with Scheffe's multiple comparison test, P<0.001). Animals fed a high-sodium diet had significantly larger endolymphatic sac lateral intercellular spaces than those animals fed a control diet only (analysis of variance with Scheffe's multiple comparison test, P<0.001). Results of this study suggest that dietary sodium affects endolymphatic sac fluid dynamics and that other food factors may regulate sodium metabolism, and therefore endolymphatic sac function.
- Publication
Laryngoscope, 1990, Vol 100, Issue 3, p217
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1288/00005537-199003000-00001