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- Title
Effect of Opiate Receptors Blockade on Microbicidal Potential and Production of IL-1β, TNFα, and IL-10 by Peritoneal Macrophages under Stress Conditions.
- Authors
Gein, S.; Sharavieva, I.
- Abstract
Rotation stress activated spontaneous and zymosan-induced ROS production. In animals receiving naloxone against the background of rotation stress, ROS production did not increase. Immobilization stress did not change the intensity of spontaneous and zymosan-induced ROS production, but inhibited stimulated ROS production against the background of naloxone treatment. Rotation produced a naloxone-independent inhibitory effect on spontaneous and stimulated IL-1β and TNFα production by macrophages and naloxone-dependent stimulating effect on spontaneous IL-10 production. Rotation stress did not modulate stimulated IL-10 production. In case of immobilization stress, decreased IL-1β and TNFα production was observed in mice exposed to stress under conditions of opiate receptors blockade; IL-10 production was not affected by immobilization stress. Both types of stress significantly increased plasma corticosterone levels, while naloxone had no effect on corticosterone production.
- Subjects
ENDORPHIN receptors; MACROPHAGES; ZYMOSAN; IMMOBILIZATION stress; NALOXONE; LABORATORY mice
- Publication
Bulletin of Experimental Biology & Medicine, 2016, Vol 161, Issue 3, p339
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-016-3409-z