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- Title
Effect of Protein Synthesis Rhythm-Organizing Signal Persists for a Day after Single Administration of Melatonin to Rat.
- Authors
Zvezdina, N.; Malchenko, L.; Konchenko, D.; Dubovaya, T.; Brodskii, V.
- Abstract
Melatonin administered to rat intraperitoneally organizes ultradian rhythm of protein synthesis in hepatocytes that persists for 1 day after exposure to the synchronizing signal. Hepatocytes were isolated 1 day after melatonin administration and cultured on coverslips in a serum-free medium. In 24 h in culture, the kinetics of protein synthesis was analyzed. In our previous experiments, we detected a rhythm in cells isolated in 1.5 h, but not in 3 days after melatonin administration to the rat. We have found that synchronization of oscillations of the protein synthesis intensity in vivo persists over 1 day after rat exposure to melatonin. Phenylephrine, an efficient synchronizer of protein synthesis in vitro, does not organize the rhythm in vivo.
- Subjects
CELL communication; ULTRADIAN rhythms; PROTEIN synthesis; MELATONIN; LABORATORY rats
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 156, Issue 3, p323
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2340-4