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- Title
Advances in autism genetics: on the threshold of a new neurobiology.
- Authors
Abrahams, Brett S.; Geschwind, Daniel H.
- Abstract
Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility genes and an increased appreciation of the contribution of de novo and inherited copy number variation. Promising strategies are also being applied to identify common genetic risk variants. Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.
- Subjects
AUTISM; DEVELOPMENTAL disabilities; GENETICS of disease susceptibility; GENETICS; GENE expression; GENETIC regulation; NEUROBIOLOGY; COMPARATIVE studies; DISEASE susceptibility; GENES; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; PHENOTYPES; BIOINFORMATICS; EVALUATION research; OLIGONUCLEOTIDE arrays; GENE expression profiling; GENOTYPES
- Publication
Nature Reviews Genetics, 2008, Vol 9, Issue 5, p341
- ISSN
1471-0056
- Publication type
journal article
- DOI
10.1038/nrg2346