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- Title
Disease activity, treatment and long-term prognosis of adult juvenile idiopathic arthritis patients compared with rheumatoid arthritis patients.
- Authors
Takumi Matsumoto; Toshihiro Matsui; Fumio Hirano; Shigeto Tohma; Masaaki Mori
- Abstract
Objective: To evaluate the difference between adult juvenile idiopathic arthritis (JIA, starting at <16 years) and rheumatoid arthritis (RA). Methods: Data on 128 adult JIA patients were from the National Database of Rheumatic Diseases in Japan (NinJa), 2014, divided into 4 groups by period of disease onset (Group 1: 2000-2013, n=32; Group 2: 1981-1999, n=32; Group 3: 1966-1980, n=31; Group 4: 1965, n=33). Disease activity, treatment and long-term prognosis of adult JIA patients were compared with RA patients matched for sex- and disease duration in each era. Results: In Groups 1 and 2, adult JIA patients had significantly lower clinical disease activity indices (CDAI) (Group 1: adult JIA 1.5 [0.4-6.9]-vs-RA 5.3 [2.5-10.3], p=.001, Group 2: 2.6 [0.6-9.0]-vs-6.9 [3.5-11.0], p=.001, shown as median [quartile range], p-value, respectively), and had higher CDAI remission rates than RA patients (Group 1: 54.8%-vs-28.2%, p=.002, Group 2: 51.7%-vs-17.0%, p<.001). More adult JIA than RA patients in Group 1 used biologics (62.5%-vs-24.7%, p<.001). However, there were no adult JIA-vs-RA differences in joint destruction and physical function in any group. Conclusions: Adult rheumatologists must recognize that adult JIA patients are different from RA patients even when disease duration is the same.
- Subjects
JUVENILE idiopathic arthritis; RHEUMATOID arthritis; PROGNOSIS; DISEASES; DISEASE duration
- Publication
Modern Rheumatology, 2020, Vol 30, Issue 1, p78
- ISSN
1439-7595
- Publication type
Article
- DOI
10.1080/14397595.2018.1554228