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- Title
Association of dietary intake with joint space narrowing and osteophytosis at the knee in Japanese men and women: the ROAD study.
- Authors
Muraki, Shigeyuki; Akune, Toru; En-yo, Yoshio; Yoshida, Munehito; Tanaka, Sakae; Kawaguchi, Hiroshi; Nakamura, Kozo; Oka, Hiroyuki; Yoshimura, Noriko
- Abstract
Objective. The objective of the present study is to identify dietary nutrients associated with joint space narrowing (JSN) and osteophytosis at the knee in a population-based cohort of the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study. Methods. From the baseline survey of the ROAD study, 827 participants (305 men and 522 women) in a rural cohort were analyzed. Dietary nutrient intakes for the last month were assessed by a self-administered brief diet history questionnaire. Minimum joint space width (mJSW) and osteophyte area (OPA) in the medial compartment of the knee were measured using a knee osteoarthritis (OA) computer-aided diagnostic system. Results In men, there were no associations of dietary nutrient intakes with mJSW or OPA. In women, vitamins K, B1, B2, B6, and C were associated with mJSW after adjustment for age, body mass index, and total energy ( p < 0.05). Vitamins E, K, B1, B2, niacin, and B6 were significantly associated with OPA ( p < 0.05) in women. Vitamins K, B and C may have a protective role against knee OA in women and might lead to disease-modifying treatments. Conclusions. The present study revealed that low dietary intake of vitamins K, B, and C are associated with JSN and osteophytosis in women.
- Subjects
FOOD consumption; JOINT diseases; BONE spurs; OSTEOPOROSIS; COHORT analysis; DIETARY supplements; QUESTIONNAIRES
- Publication
Modern Rheumatology, 2014, Vol 24, Issue 2, p236
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/14397595.2013.854055