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- Title
T1 mapping in patients with cervical spinal canal stenosis with and without decompressive surgery: A longitudinal study.
- Authors
Stefanie, Meyer; Antonia, Geiger; Leah Shyela, Volnhals; Sabine, Hofer; Peter, Dechent; Jens, Frahm; Daniel, Behme; Christian, Brelie; Veit, Rohde; Mathias, Bähr; Jan, Liman; Ilko L, Maier
- Abstract
Background and Purpose: Cervical spinal canal stenosis (cSCS) is a common cause of spinal impairment in the elderly. With conventional magnetic resonance imaging (MRI) suffering from various limitations, high‐resolution single‐shot T1 mapping has been proposed as a novel MRI technique in cSCS diagnosis. In this study, we investigated the effect of conservative and surgical treatment on spinal cord T1 relaxation times in cSCS. Methods: T1‐mapping was performed in 54 patients with cSCS at 3 Tesla MRI at the maximum‐, above and below the stenosis. Subsequently, intraindividual T1‐differences (ΔT1) intrastenosis were calculated. Twenty‐four patients received follow‐up scans after 6 months. Results: Surgically treated patients showed higher ΔT1 at baseline (154.9 ± 81.6 vs. 95.3 ± 60.7), while absolute T1‐values within the stenosis were comparable between groups (863.7 ± 89.3 milliseconds vs. 855.1 ± 62.2 milliseconds). In surgically treated patients, ΔT1 decreased inverse to stenosis severity. After 6 months, ΔT1 significantly decreased in the surgical group (154.9 ± 81.6 milliseconds to 85.7 ± 108.9 milliseconds, p =.021) and remained unchanged in conservatively treated patients. Both groups showed clinical improvement at the 6‐month follow‐up. Conclusions: Baseline difference of T1 relaxation time (ΔT1) might serve as a supporting marker for treatment decision and change of T1 relaxation time might reflect relief of spinal cord narrowing indicating regenerative processes. Quantitative T1‐mapping represents a promising additional imaging method to indicate a surgical treatment plan and to validate treatment success.
- Subjects
SPINAL stenosis; SPINAL canal; MAGNETIC resonance imaging; LONGITUDINAL method; SPINAL cord
- Publication
Journal of Neuroimaging, 2024, Vol 34, Issue 3, p329
- ISSN
1051-2284
- Publication type
Article
- DOI
10.1111/jon.13195