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- Title
Is there more to BARD1 than BRCA1?
- Authors
Irminger-Finger, Irmgard; Jefford, Charles Edward
- Abstract
It has been over a decade since mutations in BRCA1 and BRCA2 were found to be associated with a small number of familial breast cancer cases. BRCA1 is a large protein that interacts with many other proteins that have diverse functions, so it has been a challenge to determine how defects in its function could lead to cancer. One particular protein, BARD1, seems to be an important regulator of the tumour-suppressor function of BRCA1, as well as acting as a tumour suppressor itself. BARD1 is indispensable for cell viability, so loss-of-function mutations are rare, but mutations and truncations that alter its function might be involved in the pathogenesis of breast cancer.
- Subjects
BREAST cancer; PROTEINS; TUMOR suppressor proteins; CANCER cells; CARCINOGENESIS; BREAST tumor diagnosis; BREAST tumors; COMPARATIVE studies; DISEASE susceptibility; ENZYMES; FORECASTING; RESEARCH methodology; MEDICAL cooperation; GENETIC mutation; RESEARCH; EVALUATION research
- Publication
Nature Reviews Cancer, 2006, Vol 6, Issue 5, p382
- ISSN
1474-175X
- Publication type
journal article
- DOI
10.1038/nrc1878