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- Title
Factors Affecting Antibody Mediated Immune Response in Weaned Brahman Calves.
- Authors
Cook, C. L.; Garcia, T. J.; Lewis, A. W.; Neuendorff, D. A.; Bray, J.; Mwangi, W.; Randel, R. D.; Welsh, T. H.
- Abstract
Immune function could be a tool to select healthier cattle. The hypothesis of this study was that sex, BW, body condition score (BCS), or weaning temperament [e.g., (pen score (PS), exit velocity (EV), and temperament score (TS)] would influence antibody-mediated immune response (AMIR) in weaned Brahman calves. Bulls (n = 55; BW = 199 ± 10 kg; BCS = 5.4 ± 0.08) and heifers (n = 57; BW = 178 ± 10 kg; BCS = 5.3 ± 0.08) were administered Salmonella Newport Extract vaccine (2 mL subcutaneously; Zoetis, Florham Park, NJ) at a mean of 264 d of age (Day 0). Blood samples were collected by jugular venipuncture on Days 0 and 15. Harvested serum samples were stored at -20C until analyzed for vaccine specific IgG by a double sandwich, enzyme linked immunosorbent assay (AMIR). Data were analyzed using PROC MIXED procedures specific for repeated measures (SAS v9.3). Calf sex, sire, and their interaction were independent variables, and AMIR response and weaning temperament were dependent variables. Day 0 BW was greater (P = 0.0003) in bulls (199.77 ± 10.19 kg) than heifers (177.90 ± 10.30 kg). Both PS and TS were greater (P < 0.01) respectively in heifers (2.38 ± 0.13 and 2.49 ± 0.14) than in bulls (1.68 ± 0.13 and 2.01 ± 0.14). The AMIR was not different (P > 0.8) between bulls (0.49 ± 0.05) and heifers (0.48 ± 0.05). Low (L), medium (M), and high (H) immune response classes were determined by ½ SD from AMIR response means: bulls (P < 0.01, L = 0.12 ± 0.04; M = 0.46 ± 0.04; H = 1.1 ± 0.05) and heifers (P < 0.01; L = 0.18 ± 0.0; M = 0.44 ± 0.03; H = 0.93 ± 0.32). Response class was used as the independent variable in a mixed model analyses with growth and temperament measures as dependent variables. In response class data there were no significant effects of growth or temperament traits on AMIR (P > 0.10). We must accept the null hypothesis that neither sex, BW, BCS, nor weaning temperament affected AMIR in weaned Brahman calves.
- Subjects
CALVES; IMMUNE response; ENZYME-linked immunosorbent assay; ANIMAL health
- Publication
Journal of Animal Science, 2017, Vol 95, p31
- ISSN
0021-8812
- Publication type
Abstract
- DOI
10.2527/ssasas2017.062