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- Title
The effects of immunization against LHRH using recombinant LHRH fusion protein OL on testicular development, ultrasonographic and histological appearance of the testis in buck kidxs.
- Authors
Ülker, H.; Küçük, M.; Yilmaz, A.; Yörük, M.; Arslan, L.; de Avila, D. M; Reeves, J. J.
- Abstract
The purpose of this study is to evaluate the effectiveness of recombinant ovalbumin-LHRH-7 (OL) fusion protein on reproductive traits in buck kids. Twenty buck kids at 18 wk of age were divided into control (C, n = 10) and immunization (I, n = 10) groups. Immunized animals received OL protein generated by recombinant DNA technology. Ultrasonographic and histological examination of the testes was performed. Animals were slaughtered at 44 wk of age. Semen and epididymis were evaluated for the presence of sperm cells. Testicular and accessory glands development and sperm production were suppressed in the immunized animals. Semineferous tubule diameters decreased, basal membrane of the tubule was thickened and hyalinized in immunized buck kids. Immunization affected ultrasonographic appearance of the testes drastically. While testes of control animals gained their normal ultrasonographic appearance as the age increased, immunized animals had uniform hypoechogenic testicular structure as observed at 18 wk of age until slaughter. In conclusion, these results indicate that recombinant ovalbumin-LHRH-7 fusion protein is effective in immunocastration in buck kids and has a potential to be used as an alternative to physical castration.
- Subjects
CHIMERIC proteins; TESTIS; RECOMBINANT DNA; IMMUNIZATION; MALE reproductive organs; RECOMBINANT proteins
- Publication
Journal of Animal Science, 2006, Vol 84, p434
- ISSN
0021-8812
- Publication type
Article