We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cardioprotective Effect of Sulphonated Formononetin on Acute Myocardial Infarction in Rats.
- Authors
Shumin Zhang; Xuexi Tang; Jingwei Tian; Chunmei Li; Guanbo Zhang; Wanglin Jiang; Zunting Zhang
- Abstract
This study was designed to investigate the therapeutic effect of sodium formononetin-3′-sulphonate (Sul-F), a water-soluble derivate of formononetin, on acute myocardial infarction in rats. The results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase and cardiac troponin T in serum and reduced the myocardium necrosis scores. The number of apoptosis cardiocytes is well accordance with the up-regulated expression of Bcl-2 and the down-regulated expression of Bax. Meanwhile, Sul-F significantly increased the cardiac mitochondrial ATP content, improved ATP synthase activity, decreased thiobarbituric acid-reactive substances content and attenuated the decrease in superoxide dismutase and glutathione peroxidase activities. These findings indicate that Sul-F has a protective potential against myocardial infarction injury. A possible mechanism for the protective effect is the elevated expression of endogenous antioxidant defence enzymes degraded lipid peroxidation products and improved energy metholism of cardiac mitochondrial, thus attenuating cardiocyte apoptosis.
- Subjects
CARDIOTONIC agents; MYOCARDIAL infarction treatment; SODIUM; CREATINE kinase; LACTATE dehydrogenase; ALANINE aminotransferase; APOPTOSIS; HEART cells; THERAPEUTICS
- Publication
Basic & Clinical Pharmacology & Toxicology, 2011, Vol 108, Issue 6, p390
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2011.00676.x