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- Title
Ventilator-Associated Pneumonia Due to MRSA vs. MSSA: What Should Guide Empiric Therapy?
- Authors
Colaneri, Marta; Di Carlo, Domenico; Amatu, Alessandro; Marvulli, Lea Nadia; Corbella, Marta; Petazzoni, Greta; Cambieri, Patrizia; Muzzi, Alba; Bandi, Claudio; Di Matteo, Angela; Sacchi, Paolo; Mojoli, Francesco; Bruno, Raffaele
- Abstract
The guidelines on ventilator-associated pneumonia (VAP) recommend an empiric therapy against methicillin-resistant Staphylococcus aureus (MRSA) according to its prevalence rate. Considering the MRSA and MSSA VAP prevalence over the last 9 years in our tertiary care hospital, we assessed the clinical value of the MRSA nasal-swab screening in either predicting or ruling out MRSA VAP. We extracted the data of 1461 patients with positive bronchoalveolar lavage (BAL). Regarding the MRSA nasal-swab screening, 170 patients were positive for MRSA or MSSA. Overall, MRSA had a high prevalence in our ICU. Despite the COVID-19 pandemic, there was a significant downward trend in MRSA prevalence, while MSSA remained steady over time. Having VAP due to MRSA did not have any impact on LOS and mortality. Finally, the MRSA nasal-swab testing demonstrated a very high negative predictive value for MRSA VAP. Our results suggested the potential value of a patient-centered approach to improve antibiotic stewardship.
- Subjects
VENTILATOR-associated pneumonia; METHICILLIN-resistant staphylococcus aureus; ANTIMICROBIAL stewardship; COVID-19 pandemic
- Publication
Antibiotics (2079-6382), 2022, Vol 11, Issue 7, p851
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics11070851