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- Title
Recent Advances in Cancer Immunotherapy with a Focus on FDA-Approved Vaccines and Neoantigen-Based Vaccines.
- Authors
Hargrave, Anna; Mustafa, Abu Salim; Hanif, Asma; Tunio, Javed H.; Hanif, Shumaila Nida M.
- Abstract
Cancer immunotherapies refer to the concept of retraining the immune system to target malignant cells. Multiple immunotherapeutic options exist including immune modulating antibodies, immune stimulating cytokines, chimeric antigen receptor T cell therapy, and vaccines. Overall, this field has advanced rapidly as knowledge of the tumor microenvironment, immunological pathways, and biotechnology expands. Specifically, advancements in neoantigen identification, characterization, and formulation into a vaccine show promise. This review is focused on previously United States Food and Drug Administration-approved cancer therapeutic vaccines and neoantigen-based vaccine developments along with the associated relevant clinical trials.
- Subjects
UNITED States. Food &; Drug Administration; CHIMERIC antigen receptors; CANCER vaccines; VACCINES; IMMUNOTHERAPY; CANCER cells
- Publication
Vaccines, 2023, Vol 11, Issue 11, p1633
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines11111633