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- Title
B-Cell-Based Immunotherapy: A Promising New Alternative.
- Authors
Gupta, Sneh Lata; Khan, Naeem; Basu, Srijani; Soni, Vijay
- Abstract
The field of immunotherapy has undergone radical conceptual changes over the last decade. There are various examples of immunotherapy, including the use of monoclonal antibodies, cancer vaccines, tumor-infecting viruses, cytokines, adjuvants, and autologous T cells carrying chimeric antigen receptors (CARs) that can bind cancer-specific antigens known as adoptive immunotherapy. While a lot has been achieved in the field of T-cell immunotherapy, only a fraction of patients (20%) see lasting benefits from this mode of treatment, which is why there is a critical need to turn our attention to other immune cells. B cells have been shown to play both anti- and pro-tumorigenic roles in tumor tissue. In this review, we shed light on the dual nature of B cells in the tumor microenvironment. Furthermore, we discussed the different factors affecting the biology and function of B cells in tumors. In the third section, we described B-cell-based immunotherapies and their clinical applications and challenges. These current studies provide a springboard for carrying out future mechanistic studies to help us unleash the full potential of B cells in immunotherapy.
- Subjects
B cells; B cell receptors; CHIMERIC antigen receptors; T cells; CLINICAL medicine
- Publication
Vaccines, 2022, Vol 10, Issue 6, pN.PAG
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines10060879