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- Title
Hepatocyte transplantation: State of the art
- Authors
Galvão, Flávio Henrique Ferreira; de Andrade Júnior, Dahir Ramos; de Andrade, Dahir Ramos; Martins, Bruno Costa; Marson, Allan Garms; Bernard, Christiano Vinicius; dos Santos, Sânia Alves; Bacchella, Telesforo; Machado, Marcel Cerqueira César
- Abstract
Abstract: Advances in biotechnology have allowed hepatocyte transplantation as a relevant proposition to treat liver disease. This procedure may change the crescent mortality in liver transplantation waiting lists due global organ shortage. Recent clinical trials have described promising results of hepatocyte transplantation for acute, acute-on-chronic and metabolic liver disease. In this report, we discuss progresses regarding hepatocyte culture, cryopreservation systems, hepatocyte immortalization, suitable recipient site for hepatocyte engraftment, cell differentiation and fusion into hepatocytes, current clinical trials, and summarize the bioartificial liver systems. These progressions motivate expectation concerning hepatocyte transplantation as a consistent therapy for liver disease.
- Subjects
TRANSPLANTATION of organs, tissues, etc.; LIVER cells; LIVER diseases; CRYOPRESERVATION of organs, tissues, etc.; CRYOPRESERVATION of cells
- Publication
Hepatology Research, 2006, Vol 36, Issue 4, p237
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1016/j.hepres.2006.08.008