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- Title
醒脾养儿颗粒联合多潘立酮对功能性消化不良患儿血清胃肠激素、 胃蛋白酶原和炎症因子的影响.
- Authors
秦 艳; 秦海荣; 杜丽芳; 金 翠; 赵 青
- Abstract
To observe the effects of Xingpi Yanger granule combine with domperidone on serum gastrointestinal hormones, pepsinogen and inflammatory factors in children with functional dyspepsia (FD). 97 children with FD who were treated in our hospital from January 2019 to December 2021 were selected, they were randomly divided into control group and study group, the number of cases were 48 and 49 respectively. The children in the control group were treated with domperidone, the children in the study group were treated with Xingpi Yanger granule combined with domperidone. The efficacy, clinical symptom relief, serum gastrointestinal hormones, pepsinogen, inflammatory factors and adverse reactions were compared between the two groups. The total clinical effective rate of the study group (91.84% ) was higher than that of the control group (75.00% ), and the difference was statistically significant (P<0.05). The relief time of abdominal distension, nausea and vomiting, abdominal pain and anorexia in the study group were shorter than those in the control group (P<0.05). 14 d after treatment, the levels of gastrin (GAS), motilin (MTL), pepsinogen I (PGI) and pepsinogen II (PGII) in the study group were higher than those in the control group (P<0.05). 14 d after treatment, the levels of interleukin-10 (IL-10), tumor necrosis factor-α(TNF-α), somatostatin (SS), interleukin-6 (IL-6) and c-reactive protein (CRP) in the study group were lower than those in the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Xingpi Yanger granule combine with domperidone in the treatment of FD children can promote the improvement of symptoms and improve the total clinical effective rate, which may be related to the effective regulation of serum gastrointestinal hormone, pepsinogen and inflammatory factor levels.
- Subjects
GASTROINTESTINAL hormones; PEPSINOGEN; C-reactive protein; ABDOMINAL pain; INTERLEUKIN-10
- Publication
Progress in Modern Biomedicine, 2022, Vol 22, Issue 24, p4725
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2022.24.024